A study on the significance of anti-endothelial cell antibodies in chronic obstructive pulmonary disease and the effect of methylprednisolone intervention
DOI: 10.14800/ics.1210
Abstract
Objective: The purpose was to confirm the significance of Anti-endothelial cell antibodies(AECA) in chronic obstructive pulmonary disease (COPD) and validate the effect of methylprednisolone intervention.
Methods: We recruited 40 patients with stable COPD, 40 patients with an acute exacerbation of COPD, and 20 healthy volunteers from March 2019 to August 2021. The healthy volunteers constituted the healthy control group. All patients with stable COPD were divided into the mild-moderate COPD group and the severe-very severe COPD group, for whom AECA and vascular endothelial growth factor (VEGF) in peripheral blood were detected by ELISA. The patients with acute exacerbation of COPD were divided into routine treatment group and methylprednisolone group by random number method. The routine group received routine treatment, and the methylprednisolone group was treated with methylprednisolone on the basis of routine treatment, and the course of treatment was 1 week, respectively. The AECA and VEGF in the peripheral blood of the two groups of patients before and after treatment were detected by ELISA.
Results: Compared to control group, the AECA concentration was significantly elevated as the condition of COPD got serious between mild-moderate COPD group and the severe-very severe COPD group(P<0.05). And VEGF concentration was significantly lower as the condition of COPD got serious(P<0.05). AECA concentration was significantly lower after methylprednisolone treatment than before in patients with COPD exacerbation, and significantly lower than patients receiving the routine treatment (P<0.05). Besides, VEGF concentration was significantly elevated in patients with COPD exacerbation after methylprednisolone treatment than before, and considerably higher than patients receiving the routine treatment (P<0.05).
Conclusion: AECAs may be involved in the occurrence and development of COPD and related to its severity. Methylprednisolone can help reduce AECA expression while promoting VEGF expression.
