RNA processing and ribosome biogenesis in bone marrow failure dsorders

DOI: 10.14800/rd.1531

Authors

  • William Blalock, Manuela Piazzi, Angela Gallo, Alberto Bavelloni, Enrico Focaccia, Irene Faenza

Abstract

Bone marrow failure disorders (BMFDs), which are characterized by an early pro-apoptotic phase which results in faulty hematopoiesis and anemia, more often than not progress to outright acute myelogenous leukemia (AML). Recent findings have indicated that most if not all of these disorders have a very significant RNA processing component to their pathology. This review aims to highlight some of normal processes of RNA metabolism that have been recently demonstrated to be altered in BMFDs.

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Published

2019-04-03

Issue

Vol. 6 (2019)

Section

Review