In vivo anti-inflammatory activity of β-caryophyllene, evaluated by molecular imaging

Saad Sabbar Dahham, Yasser M. Tabana, Mohamed B. Khadeer Ahamed, Amin M.S. Abdul Majid


We have recently reported that β-caryophyllene (BCP) can suppress metastasis of colon cancer, induce apoptosis, and inhibit a broad spectrum of microorganisms. Here, we report anti-inflammatory effect of BCP in the carrageenan-induced edema paw model, supported by molecular imaging using fluorescence molecular tomography (FMT). A significant (p<0.01) reduction in paw volumes, and low intensity of fluorescent signal was noted in experimental animals when compared with negative control.  Noteworthy, the low toxicity of BCP and its high ability of skin penetration attributed to the strong anti-inflammatory and analgesic properties. Intriguingly, BCP is a common component of the essential oils, spices and food plants and major constituent of Cannabis, which is recognized as natural selective agonist to the CB2 receptor.  Collectively, the result of present study illustrate that the anti-inflammatory properties of BCP could be beneficial for prevention and management inflammation-related diseases.  

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