Tumor microenvironment: The promising target for tumor therapy

Jian Guan, Jie Chen

Abstract


Cancer associated fibroblast cells(CAFs) are activated fibroblast cells in tumor microenvironment, which are involved in the development of tumors. Recently, more and more researches about tumor treatment are foced on targeting CAFs in tumor microenvironment to alleviate the supportive effect of CAFs to tumor cells. In this brief report, we discussed our work about indirect effect of retinoic acid(RA) to tumor migration, which was through the inhibition of IL-6 secretion of CAFs by RA and the downregulation of IL-6 of CAFs related with inhibition of epithelial-mesenchymal transition(EMT) of tumor cell. Furthermore, our ongoing and future work is about the relationship of cell factors secreted by tumor microenvironment and the growth of tumor cells to evaluate more about the effect of tumor microenvironment to parenchymal cells.


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DOI: http://dx.doi.org/10.14800/ccm.81

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Copyright (c) 2014 Jian Guan, Jie Chen

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