Targeting cancer associated fibroblasts for cancer immunotherapy

Xiao-Tong Song


While clinical studies have shown that immunotherapies, such as vaccines, can induce cancer-specific immune responses, their antitumor efficacy has been suboptimal. Increasing evidences have suggested that antitumor efficacy of cancer immunotherapies could be limited by the presence of cancer associated fibroblasts (CAFs). CAFs express fibroblast activation protein (FAP), a membrane bound serine protease, providing an attractive immunotherapeutic target. To target FAP, a dendritic cell (DC) vaccine expressing FAP has been generated. This review summarized the progress of the emerging field of FAP-targeted cancer immunotherapy.

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Copyright (c) 2014 Xiao-Tong Song

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This work is licensed under a Creative Commons Attribution 4.0 International License.