Traceable therapeutic strategy for treatment of breast cancer with mesenchymal stem cells (MSCs)

Yuebing Wang, Zongjin Li

Abstract


With the ability of tropism towards tumors, mesenchymal stem cells (MSCs) have been considered to be attractive delivering vehicles for antitumor therapy. Molecular imaging has enabled the noninvasive monitoring of specific molecular and cellular processes in vivo, as well as evaluation of targeted cancer therapy. We recently exploited bioluminescence imaging (BLI) and near infrared (NIR) imaging to evaluate the interaction between human umbilical cord MSCs (hUC-MSCs) and pre-established tumor. Our results revealed that the transplanted hUC-MSCs played a critical antitumor role in vivo in a human breast cancer xenograft model by inhibiting tumor angiogenesis and inducing cell apoptosis. Our finding demonstrates that molecular imaging is a powerful tool in tracking cell delivery and tumor response to hUC-MSCs therapies as well as cellular and molecular processes in tumor, which will eventually benefit the development and optimization of methods for effective cancer diagnosis and therapy.


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DOI: http://dx.doi.org/10.14800/ccm.198

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Copyright (c) 2014 Yuebing Wang, Zongjin Li

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